Ligament property optimization within a virtual biomechanical knee

Jeffrey E. Bischoff, Eik Siggelkow, Daniel Sieber, Mariana Kersch, Heidi Ploeg, and Marc Münchinger
Proceedings of the ASME Summer Bioengineering Conference (SBC2008)

The goal of this work was to utilize inverse finite element (FE) analysis to determine material parameters of ligaments in a specimen-specific model of the knee, using both local and global optimization algorithms. Several optimization algorithms were considered: local algorithms LSQNONLIN and FMINCON in Matlab, quadratic programming (QP) in HEEDS, and the hybrid local/global proprietary HEEDS algorithm, SHERPA.